In 2013, DiMarco had a leading role in the independent film In the Can, an American Sign Language Films production. In 2014 and 2015, he played the recurring role of Garrett Banducci in Switched at Birth on the Freeform network.DiMarco was doing freelance modeling for about a year before he was contacted by America's Next Top Model producers in 2015. They scouted him via his social media without realizing he was deaf. He was named the winner of the season after beating out Mamé Adjei in the season finale. He is the only deaf contestant in the show's history, and the second male to win.Shortly after winning the competition, DiMarco signed with Wilhelmina Models in New York City.On March 8, 2016, DiMarco was announced as one of the celebrities who would compete on season 22 of Dancing with the Stars. He was partnered with professional dancer Peta Murgatroyd. DiMarco is the second deaf contestant to compete on the show (see Marlee Matlin). On May 24, 2016, DiMarco and Murgatroyd were announced as the winners of the season.In 2016, DiMarco will appear in the Hulu comedy series Difficult People.In June 2016, DiMarco walked for Giorgio Armani at Milan Fashion Week Spring/Summer 2017.